Name: Mouse Monoclonal Anti-SMC1A Antibody (4C5-C8-A11)
SKU: 01014298668
Price: 338 EUR
Availability: InStock

Scientific context

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

Additional description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Package form

Affinity purified antibody is supplied in liquid form in PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol

Handling and storage

Before use gently mix the antibody solution. Store this antibody at -20 °C for 12 months. Refer to the label on vial

Target

SMC1A (Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb1.8, SMC1A)

Antibody's positive controles

Western blot: MOLT-4, U87 MG and Hela NE cell lysates; Immunofluorescence: HeLa cells

Immunogen

Recombinant human SMC1A (C-term) protein fragments expressed in E.coli

Precautions

Manifactured in USA. For Research Use Only! Not to be used in humans

Released

This antibody is available to order since May 2017

Approved applications with antibody dilution

Western blot; 1:1000, Immunofluorescence; 1:100

Description

Mouse Monoclonal antibody to detect SMC1A

Clonality

Monoclonal Antibody (Clone#4C5-C8-A11)

Delivery

Shipped to your lab under gel pack

Research area

Signal Transduction

Purity

Affinity purified

Physical state

Colorless liquid

Latin name

Mus musculus

French translation

anticorps

Protein number

Q14683

Raised in

Mouse

Reacts with

Human

Gene number

8243

Mouse Monoclonal Anti-SMC1A Antibody (4C5-C8-A11)

Size

Price

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