Anti-MC-1R/MC1 Receptor (Polyclonal), ALEXA Fluor 594

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Size

100 microliters

Catalog no

GENTObs-1419R-A594
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Background information

This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Advisory

Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Cross Reactive Species details

No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Synonyms

CMM5; MC1-R; MC1R; Melanocortin 1 receptor; Melanocortin 1 receptor alpha melanocyte stimulating hormone receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; Melanotropin receptor; MSH-R; MSHR; MSHR_HUMAN; SHEP2.

Storage

Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Cross reactive species

Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)

Specificity

This antibody reacts specifically with MC-1R/MC1 Receptor

Antigen Source

KLH conjugated synthetic peptide derived from human MC-1R

Modification

No modification has been applied to this antibody

Properties

For facs or microscopy Alexa 1 conjugate.

Also known as

MC-1R/MC1 Receptor Polyclonal Antibody

Other name

Anti-MC-1R/MC1 Receptor Polyclonal

Host organism

Rabbit (Oryctolagus cuniculus)

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Type

Conjugated Primary Antibody

Group

Polyclonals and antibodies

Purification method

Purified by Protein A.

Clone

Polyclonal Antibodies

Clonality

Polyclonal Antibody

Applications with corresponding dilutions

IF(IHC-P)(1:50-200)

Target Protein/Peptide

MC-1R/MC1 Receptor

Conjugated with

ALEXA FLUOR® 594

Conjugated

Alexa conjugate 1

Concentration

1ug per 1ul

Excitation emission

590nm/617nm

Applications

IF(IHC-P)

Subcellular locations

Cytoplasm

Modification site

None

Gene ID

4157

Swiss Prot

N/A

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