SMC1(Ser957) Antibody

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Size

0.1ml

Catalog no

bs-3407R
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Background of the target antigen

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonym names

SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1A; KIAA0178

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Specificity

This is a highly specific antibody against SMC1 Ser957. This phosphorylation site is homologous across the listed species.

Source

KLH conjugated synthetic phosphopeptide derived from human SMC1 around the phosphorylation site of Ser957 [GS(p-S)QG]

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Recommended dilutions

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Purification method

This antibody was purified via Protein A.

Long name

SMC1(Ser957) Primary Polyclonal Antibody

Tested Applications

WB, IHC-P, IF(IHC-P)

Clone number

Polyclonal antibody

Clonality

Polyclonal antibody

Category

Primary Antibodies

Also known as

SMC1(Ser957) PAb

Modification(s)

Phosphorylation

Immunogen range

930-980/1233

Cross reactivity

Human, Mouse

Conjugation

Unconjugated

Concentration

1ug per 1ul

Target Antigen

SMC1 Ser957

French translation

anticorps

Subcellular location

Nucleus

Swiss Prot

Q14683

Modification site(s)

Ser957

Gene ID number

8243

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