(R)-3-(7-((2,4-Difluorobenzyl)carbamoyl)-9-hydroxy-1,8-dioxo-3,4-dihydro-1H-pyrido[1,2-a]pyrazin-2(8H)-yl)butyl 2,4-difluorobenzylcarbamate

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Size

1 mg

Catalog no

D447200
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Chemical's main applications

(R)-3-(7-((2,4-Difluorobenzyl)carbamoyl)-9-hydroxy-1,8-dioxo-3,4-dihydro-1H-pyrido[1,2-a]pyrazin-2(8H)-yl)butyl 2,4-difluorobenzylcarbamate is impurity F of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Cas number

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Other name

Dolutegravir impurity F

Physical properties

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Melting temperature

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Boiling temperature

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Chemical's soluble in

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Stability conditions

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Chemical's formula

C28H24F4N4O6

Chemical's molecular weight

588.51

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