2'-(R)-Hydroxy-2',3'-dihydroabacavir Dihydrochloride

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Size

0,5 mg

Catalog no

H939485
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Chemical's main applications

2'-(R)-Hydroxy-2',3'dihydroabacavir is the impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Cas number

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Chemical available in other sizes

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Other name

3-Hydroxy Abacavir

Chemical's formula

C14H20N6O2•2HCl

Physical properties

No Data Available

Melting temperature

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Boiling temperature

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Chemical's soluble in

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Stability conditions

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Storage

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Chemical's molecular weight

304.357292

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