Name: Anti-GDF15/MIC-1 (Polyclonal), ALEXA Fluor 594
SKU: 01010603627
Price: 489 EUR
Availability: InStock

Background information

Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

Advisory

Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Synonyms

PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; GDF15

Cross Reactive Species details

No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Storage

Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Cross reactive species

Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)

Antigen Source

KLH conjugated synthetic peptide derived from human GDF-15

Specificity

This antibody reacts specifically with GDF15/MIC-1

Modification

No modification has been applied to this antibody

Properties

For facs or microscopy Alexa 1 conjugate.

Also known as

GDF15/MIC-1 Polyclonal Antibody

Host organism

Rabbit (Oryctolagus cuniculus)

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Other name

Anti-GDF15/MIC-1 Polyclonal

Type

Conjugated Primary Antibody

Group

Polyclonals and antibodies

Purification method

Purified by Protein A.

Clone

Polyclonal Antibodies

Clonality

Polyclonal Antibody

Applications with corresponding dilutions

IF(IHC-P)(1:50-200)

Conjugated with

ALEXA FLUOR® 594

Conjugated

Alexa conjugate 1

Concentration

1ug per 1ul

Excitation emission

590nm/617nm

Target Protein/Peptide

GDF15/MIC-1

Applications

IF(IHC-P)

Subcellular locations

Secreted

Swiss Prot

Q99988

Modification site

None

Gene ID

9518

Anti-GDF15/MIC-1 (Polyclonal), ALEXA Fluor 594

Size

Price

Catalog no

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