DMC1 Antibody, Cy3 Conjugated

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Size

0.1ml

Catalog no

bs-13010R-Cy3
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Antigen background

DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.

Properties

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-DMC1 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.

Synonyms

disrupted meiotic cDNA 1 homolog; dJ199H16.1; DMC 1; DMC1 dosage suppressor of mck1 homolog; DMC1 dosage suppressor of mck1 homolog meiosis specic homologous recombination yeast; DMC1 homologue; DMC1H; HsLim15; LIM15; Meiotic recombination protein DMC1/LIM15 homolog; MGC150472; MGC150473; DMC1_HUMAN.

Storage conditions

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

Crossreactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source

KLH conjugated synthetic peptide derived from human DMC1

Specificity

This is a highly specific antibody against DMC1.

Purification method

This antibody was purified via Protein A.

Long name

DMC1 Polyclonal Antibody, Cy3 Conjugated

Host Organism

Rabbit (Oryctolagus cuniculus)

Category

Conjugated Primary Antibodies

Excitation Emission

512,550nm/570,615nm

Recommended dilutions

IF(IHC-P)(1:50-200)

Additional conjugation

cy3 conjugation kit

Clone

Polyclonal antibody

Crossreactivity

Human, Mouse, Rat

Concentration

1ug per 1ul

Clonality

Polyclonal

Modification

Unmodified

French translation

anticorps

Tested applications

IF(IHC-P)

Gene ID number

11144

Modification site

None

Target Antigen

DMC1

Conjugation

Cy3

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