anti-RAP80 Antibody

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Size

0.02 mg, 0.1 mg

Catalog no

4327
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Gene info

RAP80 Antibody: RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.

Keep at

RAP80 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antibody advice

RAP80 antibody can be used for detection of RAP80 by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 20 ug/mL.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Gene names

RAP80 Antibody: RAP80, X2HRIP110, RAP80, RXRIP110, BRCA1-A complex subunit RAP80, Receptor-associated protein 80

Antigen

RAP80 antibody was made against a 17 amino acid synthetic peptide from near the amino terminus of human RAP80.

Purity

RAP80 Antibody is affinity chromatography purified via peptide column.

Immuno application

ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence

Suspention, pH, azide

RAP80 Antibody is supplied in PBS containing 0.02% sodium azide.

Antigene name

ubiquitin interaction motif containing 1

Antibodie's label

unlabelled serum

Source

Homo sapiens

Works with

Human, Mouse

Vial with antibody

in solution

Type

Polyclonal

Omim nr

119605449

French translation

anticorps

Ncbi nr

EAW85043

Quantity per ml

1 mg/mL

Protein nr

Q96RL1

Ab raised in

Rabbit

NCBI GENE nr

51720

GENE symbol

UIMC1

Immunoglobulin

IgG

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