GEMC1 Antibody, ALEXA FLUOR 488

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Size

100ul

Catalog no

bs-13332R-A488
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Background of the antigen

GEMC1 is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. A member of the GEMC1 family, GEMC1 is highly phosphorylated and interacts with chromatin during formation of the pre-replication complex. The gene encoding GEMC1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Properties

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-GEMC1 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GEMC1

Cross-reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Synonyms

GEMC1; Geminin coiled coil domain containing protein 1; Gm606; GEMC1_HUMAN.

Long name

GEMC1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated

Specificity

This is a highly specific antibody against GEMC1.

Also known as

Anti-GEMC1 PAb ALEXA FLUOR 488

Host Organism

Rabbit (Oryctolagus cuniculus)

Category

Conjugated Primary Antibodies

Purification

Purified by Protein A.

Recommended dilutions

IF(IHC-P)(1:50-200)

Clone

Polyclonal antibody

Crossreactivity

Human, Mouse, Rat

Conjugated with

ALEXA FLUOR® 488

Excitation emission

499nm/519nm

Concentration

1ug per 1ul

Conjugation

Alexa Fluor

Modification

Unmodified

Clonality

Polyclonal

French translation

anticorps

Tested applications

IF(IHC-P)

Gene ID Number

647309

Target Antigen

GEMC1

Modification Site

None

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