Name: Rabbit Anti Human,Rat UIMC1 Antibody-Non-conjugated
SKU: 01025640329
Price: 302 EUR
Availability: InStock

Background

Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

About

Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Properties

If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Shipping and storage

UIMC1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.

Alias

BRCA1-A complex subunit RAP80,Receptor-associated protein 80,Retinoid X receptor-interacting protein 110,Ubiquitin interaction motif-containing protein 1,UIMC1,RAP80,RXRIP110

Buffer composition

Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Immunogen type

Recombinant Human BRCA1-A complex subunit RAP80 protein (161-235AA)

Tested applications & recommended dilutions

ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:300-1:500

Long name

Rabbit Antibody against Human, Rat UIMC1, Non-conjugated

Latin name

Oryctolagus cuniculus,Rattus norvegicus

Short name of the antigen

BRCA1-A complex subunit RAP80

Synonym name

UIMC1 Human, Rat Antibody

Format

Liquid, diluted in buffer

Antibody category

Polyclonal Antibodies

Clonality

Polyclonal antibody

Purification method

Protein G purified

Conjugation

Non-conjugated

Species reactivity

Human,Rat

French translation

anticorps

UniProt ID

Q96RL1

Immunogen species

Human

Purity

>95%

Antibody isotype

IgG

Rabbit Anti Human,Rat UIMC1 Antibody-Non-conjugated

Size

Price

Catalog no

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