Name: Rabbit Anti Human SMC1A Antibody-Non-conjugated
SKU: 01025622942
Price: 168 EUR
Availability: InStock

Background

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Properties

If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

About

Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

Shipping and storage

SMC1A Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.

Alias

SMC protein 1A,SMC-1-alpha,SMC-1A,Sb1.8,SMC1A,DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1

Immunogen type

Recombinant human Structural maintenance of chromosomes protein 1A protein (1-130AA)

Long name

Rabbit Antibody against Human SMC1A, Non-conjugated

Buffer composition

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested applications & recommended dilutions

ELISA,IHC;Recommended dilution:IHC:1:20-1:200

Purification method

Antigen Affinity Purified Antibodies

Format

Liquid, diluted in buffer

Latin name

Oryctolagus cuniculus

Antibody category

Polyclonal Antibodies

Synonym name

SMC1A Human Antibody

Clonality

Polyclonal antibody

Conjugation

Non-conjugated

French translation

anticorps

UniProt ID

Q14683

Immunogen species

Human

Species reactivity