Name: Anti-HUMAN SMC1 (pSer966)
SKU: 01022531184
Price: 984 EUR
Availability: InStock

Specificity and cross-reactivity

SMC1 This item specifically recognises the human nuclear protein SMC1 (structural maintenance of chromosomes 1), when phosphorylated at Ser966. _x000D__x000D_SMC1 is a member of the evolutionary highly conserved SMC family of ATPases which play a vital role in the organization of chromosomes during mitosis. Eukaryotic SMC1 combines with SMC3, and with the two sister-chromatid cohesion proteins Scc1 and Scc3, to form the macromolecular cohesion complex, responsible for the linking of sister chromatids during metaphase. The SMC1-SMC3 heterodimer also combines with DNA polymerase E and ligase III to form the DNA recombination complex RC-1. _x000D_Studies have shown that the phosphorylation of SMC1 on residues Ser966 and Ser957 by the protein kinase ATM, occurs following irradiation damage of DNA, and is required for the activation of the ATM/NBS1-dependent S-phase checkpoint response, with the presence of BRCA1 resulting in optimal phosphorylation.

Description

productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Storage and shipping

Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.

Other names

structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1A; structural maintenance of chromosomes protein 1A; SMC-1A; SMC-1-alpha; SMC protein 1A; segregation of mitotic chromosomes 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; structural maintenance of chromosomes 1A; Sb1.8

Advisory

In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Additional description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Other gene names

SMC1A; SMC1A; SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; SMC protein 1A; SMC-1-alpha; SMC-1A

Test

MBS Polyclonals supplies antibodies that are for research of human proteins.

Tested for:

Western Blot (WB), Immunoprecipitation (IP)

Alternative name3

Lapin ANTI Homo sapiens SMC1 (pSer966)

Alternative name1

Anti-RABBIT ANTI HUMAN SMC1 (pSer966)

Alternative name2

RABBIT ANTI HUMAN SMC1 (pSer966)

Form/Appearance

Purified (Purified IgG - liquid)

Concentration

IgG concentration 1.0mg/ml

Clone

Polyclonal antibody

Immunoglobulin isotype

Polyclonal IgG

Clonality

Polyclonal

Host organism

Rabbit

Species reactivity

Human

Gene name

SMC1

Alternative name4