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(R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.
(3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (+)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; (+)-Blebbistatin;
Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
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Bright Yellow Solid
No Data Available
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-20˚C Freezer
1177356-70-5
C18H16N2O2
210-212°C
In Stock
292.33